Exhibit 22.1

List of Issuer and Guarantor Subsidiaries of Endo, Inc.

The following subsidiaries of Endo, Inc. (the “Company”) are the issuer or guarantors of the Company’s 8.500% senior secured notes due 2031.

 

Subsidiary		Jurisdiction of Incorporation or Organization		Issuer/Guarantor
Endo Finance Holdings, Inc.		Delaware		Issuer Subsidiary
Endo Enterprise, Inc.		Delaware		Guarantor Subsidiary
Endo USA, Inc.		Delaware		Guarantor Subsidiary
Endo US Holdings Luxembourg I S.a r.l.		Luxembourg		Guarantor Subsidiary
Operand Pharmaceuticals Holdco I Limited		Ireland		Guarantor Subsidiary
Endo Biologics Limited		Ireland		Guarantor Subsidiary
Endo Operations Limited		Ireland		Guarantor Subsidiary