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Exhibit 22.1
LIST OF SUBSIDIARY ISSUERS OF GUARANTEED SECURITIES
As of March 19, 2024, AstraZeneca Finance LLC, 100%-owned subsidiary of AstraZeneca PLC, a public limited company incorporated under the laws of England and Wales (the “Company”), is the issuer of the following outstanding debt securities, which are fully and unconditionally guaranteed by the Company.
| Registered U.S. Bonds | Subsidiary Issuer | Parent Guarantor |
| 0.700% Notes due 2024 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 1.200% Notes due 2026 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 1.750% Notes due 2028 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.875% Notes due 2028 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.900% Notes due 2030 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 2.250% Notes due 2031 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.875% Notes due 2033 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.800% Notes due 2027 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.850% Notes due 2029 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 4.900% Notes due 2031 | AstraZeneca Finance LLC | AstraZeneca PLC |
| 5.000% Notes due 2034 | AstraZeneca Finance LLC | AstraZeneca PLC |